CAVIN2

Across TCGA pan-cancer cohorts, CAVIN2 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CAVIN2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CAVIN2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CAVIN2 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and LSCC are the cancer types where CAVIN2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CAVIN2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	−2.263	<.001	12	view →
COAD	Male	III,IV	−2.456	<.001	11	view →
LSCC	Male	II,III,IV	−2.635	<.001	9	view →
LUAD	Female	II,III,IV	−2.458	<.001	9	view →
PDAC	Female	All	−0.686	<.001	8	view →
OV	All	All	−2.345	<.001	2	view →
CCRCC	Male	All	+0.206	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CAVIN2–HNSC

Open the HNSC breakdown →