CAVIN2

Across TCGA patient cohorts, CAVIN2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAVIN2-associated genes across cancer lineages are FOXO3a_pS318_S321, JNK2, and VHL. Each is linked with CAVIN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAVIN2-to-partner and partner-to-CAVIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by CAVIN2-low versus CAVIN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAVIN2→partner) and Y-score (partner→CAVIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.118	-1.990	.025	.030	3	2
UCEC	JNK2 →	+0.237	+2.331	.004	.019	3	2
UCEC	VHL →	-0.950	-2.000	<.001	.030	3	2
UCEC	4E-BP1 →	+0.399	+3.489	<.001	.002	3	2
SKCM	eIF4E →	+0.151	+1.289	.007	.022	3	2
SKCM	ACC1 →	+0.195	+1.498	.048	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

FOXO3a_pS318_S321 by CAVIN2 expression — UCEC

Explore this box plot interactively →