CAVIN2

Across TCGA cell cohorts, CAVIN2 mutation is significantly associated with the RNA expression of many other genes, with 57 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CAVIN2-associated genes across cancer lineages are NAT2, C20orf85, and CST8. Each is linked with CAVIN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAVIN2-to-partner and partner-to-CAVIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NAT2 grouped by CAVIN2-low versus CAVIN2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAVIN2→partner) and Y-score (partner→CAVIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NAT2 →	+0.054	+3.551	<.001	.009	3	2
BLOOD_Leukemia	C20orf85 →	+0.033	+4.384	<.001	.006	3	1
BLOOD_Leukemia	CST8 →	+0.037	+4.384	<.001	.006	3	1
BLOOD_Leukemia	SOX14 →	+0.005	+4.269	<.001	.002	3	1
BLOOD_Leukemia	MUC7 →	+0.178	+4.567	<.001	.001	3	1
BLOOD_Leukemia	SMIM32 →	+0.026	+4.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

NAT2 by CAVIN2 expression — BLOOD_Leukemia

Explore this box plot interactively →