CAV3

Across TCGA patient cohorts, CAV3 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAV3-associated genes across cancer lineages are Ku80, Myosin-IIa_pS1943, and Rab11. Each is linked with CAV3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAV3-to-partner and partner-to-CAV3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by CAV3-low versus CAV3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAV3→partner) and Y-score (partner→CAV3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.343	+3.472	.003	.002	3	1
UCEC	Myosin-IIa_pS1943 →	+0.258	+3.472	.012	.002	3	1
UCEC	Rab11 →	-0.159	-2.321	.029	.035	3	1
UCEC	STAT3_pY705 →	-0.580	-3.459	<.001	.005	3	1
UCEC	Tuberin →	+0.512	+3.459	<.001	.005	3	1
UCEC	VHL →	-1.195	-2.321	<.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Ku80 by CAV3 expression — UCEC

Explore this box plot interactively →