CAV2

Across TCGA patient cohorts, CAV2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAV2-associated genes across cancer lineages are EGFR_pY1173, GSK-3_pS9, and AMPK_pT172. Each is linked with CAV2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAV2-to-partner and partner-to-CAV2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by CAV2-low versus CAV2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAV2→partner) and Y-score (partner→CAV2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	-0.086	-3.295	.040	.010	3	1
UCEC	GSK-3_pS9 →	+0.589	+3.000	.005	.036	3	1
UCEC	AMPK_pT172 →	+0.451	+2.183	.036	.035	3	1
UCEC	Annexin-1 →	+0.761	+3.019	.005	.019	3	1
UCEC	Caspase-8 →	-0.346	-3.143	.008	.018	3	1
UCEC	eIF4E →	+0.242	+3.321	.028	.010	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

EGFR_pY1173 by CAV2 expression — UCEC

Explore this box plot interactively →