CAV1

Across TCGA pan-cancer cohorts, CAV1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CAV1 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CAV1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CAV1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

PDAC, GBM, and LSCC are the cancer types where CAV1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	II,III,IV	0.619	0.945	<.001	76	view →
GBM	DFS	Median	All	0.627	0.872	<.001	22	view →
LSCC	OS	Median	All	0.921	1.000	.010	12	view →
HNSC	DFS	Median	All	0.977	0.908	.032	5	view →
LUAD	DFS	Quartile	All	0.908	0.510	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CAV1–PDAC (DFS)

Open the PDAC breakdown →