CAV1

Across TCGA patient cohorts, CAV1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAV1-associated genes across cancer lineages are 14-3-3_beta, eEF2, and eIF4G. Each is linked with CAV1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAV1-to-partner and partner-to-CAV1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CAV1-low versus CAV1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAV1→partner) and Y-score (partner→CAV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.120	-2.780	<.001	.003	3	1
UCEC	eEF2 →	+0.364	+2.700	.004	.005	3	1
UCEC	eIF4G →	+0.230	+2.999	.039	.035	3	1
UCEC	ERK2 →	+0.173	+1.925	.012	.005	3	1
UCEC	GAPDH →	+0.380	+2.000	.049	.029	3	1
UCEC	ACC1 →	+0.317	+1.925	.015	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

14-3-3_beta by CAV1 expression — UCEC

Explore this box plot interactively →