CATSPERE

Across TCGA patient cohorts, CATSPERE mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CATSPERE-associated genes across cancer lineages are p38-MAPK_pT180_Y182, FoxM1, and MEK1. Each is linked with CATSPERE in more than 2 cancer types. Because this analysis shows association rather than direction, both CATSPERE-to-partner and partner-to-CATSPERE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by CATSPERE-low versus CATSPERE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CATSPERE→partner) and Y-score (partner→CATSPERE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.397	-1.308	.008	.030	3	3
UCEC	FoxM1 →	+0.170	+1.874	.049	.002	3	2
UCEC	MEK1 →	+0.348	+1.502	.004	.027	3	2
UCEC	mTOR_pS2448 →	-0.119	-1.794	.017	.024	3	2
UCEC	p62 Lck ligand →	+0.310	+1.331	.004	.043	3	2
UCEC	PCNA →	+0.170	+2.000	.018	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

p38-MAPK_pT180_Y182 by CATSPERE expression — UCEC

Explore this box plot interactively →