Across TCGA pan-cancer cohorts, CATSPER4 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CATSPER4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CATSPER4 RNA is repressed in tumor relative to normal tissue. In most cancer types CATSPER4 is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

KIRC, LUSC, and COAD are the cancer types where CATSPER4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CATSPER4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−0.017	.022	4	view →
LUSC	All	All	+0.036	.011	3	view →
COAD	All	All	+0.034	.005	3	view →
BRCA	All	III,IV	−0.027	.047	2	view →
KIRP	Male	All	−0.066	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: CATSPER4 RNA expression & survival · all CATSPER4 data types