CATSPER2

Across TCGA patient cohorts, CATSPER2 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CATSPER2-associated genes across cancer lineages are FASN, ACC1, and MEK1. Each is linked with CATSPER2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CATSPER2-to-partner and partner-to-CATSPER2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by CATSPER2-low versus CATSPER2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CATSPER2→partner) and Y-score (partner→CATSPER2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.404	+2.115	.003	.017	3	2
UCEC	ACC1 →	+0.354	+2.183	.005	.033	3	2
UCEC	MEK1 →	+0.429	+3.169	<.001	<.001	3	2
UCEC	PCNA →	+0.294	+2.392	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.143	-1.678	.007	.021	3	2
UCEC	Caspase-7-cleavedD198 →	+0.522	+2.019	.012	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

FASN by CATSPER2 expression — UCEC

Explore this box plot interactively →