CATSPER1

Across TCGA patient cohorts, CATSPER1 mutation is significantly associated with the RNA expression of many other genes, with 3,003 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CATSPER1-associated genes across cancer lineages are NUSAP1, POLA2, and PRC1. Each is linked with CATSPER1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CATSPER1-to-partner and partner-to-CATSPER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUSAP1 grouped by CATSPER1-low versus CATSPER1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CATSPER1→partner) and Y-score (partner→CATSPER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NUSAP1 →	+0.523	+2.373	.006	.002	3	4
UCEC	POLA2 →	+0.360	+1.661	.001	<.001	3	4
SKCM	PRC1 →	+0.501	+2.751	.005	.002	3	4
UCEC	TXN2 →	+0.297	+2.022	<.001	<.001	3	3
SKCM	EIF5 →	+0.505	+1.813	.004	.002	3	3
SKCM	PSMD9 →	+0.256	+1.839	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,003 associations by consensus.

NUSAP1 by CATSPER1 expression — SKCM

Explore this box plot interactively →