CATSPER1

Across TCGA cell cohorts, CATSPER1 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CATSPER1-associated genes across cancer lineages are IQCF5, OR11H12, and SULT6B1. Each is linked with CATSPER1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CATSPER1-to-partner and partner-to-CATSPER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by CATSPER1-low versus CATSPER1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CATSPER1→partner) and Y-score (partner→CATSPER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IQCF5 →	+0.119	+5.786	<.001	<.001	3	2
STOMACH	OR11H12 →	+0.047	+4.280	<.001	.001	3	1
LUNG_NSCLC_LUAD	SULT6B1 →	+1.213	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR6V1 →	+0.018	+5.189	<.001	<.001	3	1
LARGE_INTESTINE	ETNPPL →	+0.187	+4.021	.005	.001	3	1
LARGE_INTESTINE	UTF1 →	+0.015	+3.217	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

IQCF5 by CATSPER1 expression — BLOOD_Leukemia

Explore this box plot interactively →