CAT

Across TCGA pan-cancer cohorts, CAT mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CAT data layer compared with 28 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CAT mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CAT expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, CCRCC, and LUAD are the cancer types where CAT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	1.000	0.577	.001	24	view →
CCRCC	OS	Median	II,III,IV	0.099	0.979	.012	22	view →
LUAD	OS	Median	III,IV	0.750	0.997	.031	8	view →
HNSC	DFS	Median	III,IV	0.882	1.000	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CAT–LSCC (OS)

Open the LSCC breakdown →