CAT

Across TCGA cell cohorts, CAT RNA expression is significantly associated with the go_rna of many other GO terms, with 3,501 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CAT-associated GO terms across cancer lineages are Response to vitamin E, Response to L-ascorbic acid, and Detoxification of hydrogen peroxide. Each is linked with CAT in more than 17 cancer types. Because this analysis shows association rather than direction, both CAT-to-partner and partner-to-CAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to vitamin E grouped by CAT-low versus CAT-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CAT→partner) and Y-score (partner→CAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Response to vitamin E →	+0.168	+0.971	<.001	<.001	3	18
LUNG_SCLC	Response to L-ascorbic acid →	+0.283	+1.412	<.001	<.001	3	17
BLOOD_Leukemia	Detoxification of hydrogen peroxide →	+0.178	+1.944	<.001	<.001	3	15
BONE	UV protection →	+0.161	+1.432	<.001	<.001	3	13
LUNG_SCLC	Response to phenylpropanoid →	+1.347	+1.360	<.001	<.001	3	13
BLOOD_Leukemia	Response to light intensity →	+0.247	+1.932	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,501 associations by consensus.

Response to vitamin E by CAT expression — BONE

Explore this box plot interactively →