CAT

Across TCGA cell cohorts, CAT protein abundance is significantly associated with the go_rna of many other GO terms, with 2,271 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CAT-associated GO terms across cancer lineages are Detoxification of hydrogen peroxide, Response to L-ascorbic acid, and Response to vitamin E. Each is linked with CAT in more than 10 cancer types. Because this analysis shows association rather than direction, both CAT-to-partner and partner-to-CAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Detoxification of hydrogen peroxide grouped by CAT-low versus CAT-high in BLOOD_Leukemia.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CAT→partner) and Y-score (partner→CAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Detoxification of hydrogen peroxide →	+0.156	+2.065	<.001	<.001	3	10
STOMACH	Response to L-ascorbic acid →	+0.267	+1.671	.009	.008	2	11
STOMACH	Response to vitamin E →	+0.185	+1.845	.002	.001	2	10
LUNG_SCLC	Response to ozone →	+1.071	+1.370	.002	.003	3	7
BLOOD_Leukemia	Response to light intensity →	+0.235	+2.092	<.001	<.001	3	7
LUNG_SCLC	Response to phenylpropanoid →	+0.889	+1.143	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,271 associations by consensus.

Detoxification of hydrogen peroxide by CAT expression — BLOOD_Leukemia

Explore this box plot interactively →