CASTOR3

Across TCGA patient cohorts, CASTOR3 RNA expression is significantly associated with the protein abundance of many other proteins, with 20,945 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CASTOR3-associated proteins across cancer lineages are CASTOR2, ZNF219_S698, and MSI2. Each is linked with CASTOR3 in more than 5 cancer types. Because this analysis shows association rather than direction, both CASTOR3-to-partner and partner-to-CASTOR3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CASTOR3 versus CASTOR2 in BRCA, with a Pearson correlation of 0.46.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CASTOR3→partner) and Y-score (partner→CASTOR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CASTOR2 →	+0.522	+0.746	<.001	<.001	3	6
HNSC	ZNF219_S698 →	+0.797	+0.875	.002	<.001	3	5
HNSC	MSI2 →	+0.487	+0.819	<.001	<.001	3	5
LSCC	MYEF2 →	+0.926	+0.600	<.001	<.001	3	5
BRCA	PHC1_S664 →	+0.784	+0.507	<.001	<.001	3	5
GBM	VASP →	-0.510	-0.703	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,945 associations by consensus.

CASTOR3 vs CASTOR2 — BRCA

Explore this scatter interactively →