CASTOR3

Across TCGA patient cohorts, CASTOR3 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASTOR3-associated genes across cancer lineages are Fibronectin, FoxM1, and Caspase-7-cleavedD198. Each is linked with CASTOR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASTOR3-to-partner and partner-to-CASTOR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by CASTOR3-low versus CASTOR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASTOR3→partner) and Y-score (partner→CASTOR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.405	-3.321	.019	.010	3	1
UCEC	FoxM1 →	+0.316	+3.321	.020	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+0.779	+2.827	.012	.035	3	1
UCEC	PDCD4 →	-0.608	-3.321	.013	.010	2	1
UCEC	VHL →	-1.278	-3.321	<.001	.010	2	1
UCEC	AMPK_pT172 →	+0.515	+3.335	.016	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Fibronectin by CASTOR3 expression — UCEC

Explore this box plot interactively →