CASTOR2

Across TCGA patient cohorts, CASTOR2 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,785 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CASTOR2-associated proteins across cancer lineages are PSMB8, TRIM21, and PML. Each is linked with CASTOR2 in more than 5 cancer types. Because this analysis shows association rather than direction, both CASTOR2-to-partner and partner-to-CASTOR2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CASTOR2 versus PSMB8 in GBM, with a Pearson correlation of -0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CASTOR2→partner) and Y-score (partner→CASTOR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PSMB8 →	-0.386	-0.700	<.001	<.001	3	6
GBM	TRIM21 →	-0.515	-0.714	<.001	<.001	3	5
GBM	PML →	-0.434	-0.541	.001	.003	3	5
GBM	NONO →	+0.165	+0.507	.001	.002	3	5
GBM	TYMP →	-0.562	-0.559	<.001	<.001	3	4
GBM	TCIRG1 →	-0.523	-0.707	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,785 associations by consensus.

CASTOR2 vs PSMB8 — GBM

Explore this scatter interactively →