CASTOR2

Across TCGA patient cohorts, CASTOR2 protein abundance is significantly associated with the RNA expression of many other genes, with 9,300 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CASTOR2-associated genes across cancer lineages are CASTOR3, CNTN4, and STAG3. Each is linked with CASTOR2 in more than 5 cancer types. Because this analysis shows association rather than direction, both CASTOR2-to-partner and partner-to-CASTOR2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CASTOR2 versus CASTOR3 in BRCA, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASTOR2→partner) and Y-score (partner→CASTOR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CASTOR3 →	+0.746	+0.522	<.001	<.001	3	6
BRCA	CNTN4 →	+0.798	+0.285	<.001	.007	3	5
LSCC	STAG3 →	+0.784	+0.379	<.001	<.001	3	5
BRCA	GTF2IP4 →	+0.732	+0.556	<.001	<.001	3	5
LSCC	PVRIG →	+0.471	+0.343	<.001	<.001	3	4
BRCA	SRRM3 →	+0.802	+0.312	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,300 associations by consensus.

CASTOR2 vs CASTOR3 — BRCA

Explore this scatter interactively →