CASTOR2

Across TCGA patient cohorts, CASTOR2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASTOR2-associated genes across cancer lineages are EGFR_pY1173, ERCC1, and HSP70. Each is linked with CASTOR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASTOR2-to-partner and partner-to-CASTOR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by CASTOR2-low versus CASTOR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASTOR2→partner) and Y-score (partner→CASTOR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	-0.105	-3.301	.003	.010	3	1
UCEC	ERCC1 →	-0.161	-2.700	.038	.006	3	1
UCEC	HSP70 →	-0.379	-2.700	.036	.006	3	1
UCEC	MEK1 →	+0.326	+3.169	.048	.018	3	1
UCEC	N-Cadherin →	-0.282	-2.700	.003	.006	3	1
UCEC	p27_pT157 →	-0.063	-3.420	.016	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

EGFR_pY1173 by CASTOR2 expression — UCEC

Explore this box plot interactively →