CASTOR2

Across TCGA cell cohorts, CASTOR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,666 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CASTOR2-associated GO terms across cancer lineages are Cytosolic transport, Regulation of nucleotide-excision repair, and Endosomal transport. Each is linked with CASTOR2 in more than 15 cancer types. Because this analysis shows association rather than direction, both CASTOR2-to-partner and partner-to-CASTOR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytosolic transport grouped by CASTOR2-low versus CASTOR2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CASTOR2→partner) and Y-score (partner→CASTOR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.069	+0.737	<.001	.001	3	16
BREAST	Regulation of nucleotide-excision repair →	+0.126	+1.141	<.001	<.001	3	15
STOMACH	Endosomal transport →	+0.073	+1.107	<.001	<.001	3	15
STOMACH	Macroautophagy →	+0.082	+1.588	<.001	<.001	3	15
OESOPHAGUS	Regulation of protein sumoylation →	+0.130	+1.113	.001	<.001	3	14
BREAST	Nucleoside triphosphate biosynthetic process →	+0.086	+1.029	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,666 associations by consensus.

Cytosolic transport by CASTOR2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →