CASTOR1

Across TCGA patient cohorts, CASTOR1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,574 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CASTOR1-associated genes across cancer lineages are SCLT1, FBLIM1, and RNA5SP39. Each is linked with CASTOR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASTOR1-to-partner and partner-to-CASTOR1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CASTOR1 versus SCLT1 in HNSC, with a Pearson correlation of -0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASTOR1→partner) and Y-score (partner→CASTOR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SCLT1 →	-0.513	-0.561	.004	.001	3	2
BRCA	FBLIM1 →	+0.960	+0.323	.002	.009	3	2
HNSC	RNA5SP39 →	-1.233	-0.433	.006	.009	3	2
BRCA	SLC17A7 →	+0.499	+0.294	<.001	.002	3	2
LSCC	CD274 →	-1.517	-0.416	<.001	.001	3	2
LSCC	SMTN →	+1.003	+0.500	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,574 associations by consensus.

CASTOR1 vs SCLT1 — HNSC

Explore this scatter interactively →