CASTOR1

Across TCGA patient cohorts, CASTOR1 mutation is significantly associated with the RNA expression of many other genes, with 99 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASTOR1-associated genes across cancer lineages are RN7SKP211, RNA5SP396, and POLR2KP2. Each is linked with CASTOR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASTOR1-to-partner and partner-to-CASTOR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP211 grouped by CASTOR1-low versus CASTOR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASTOR1→partner) and Y-score (partner→CASTOR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP211 →	+0.396	+4.661	.001	.004	3	2
UCEC	RNA5SP396 →	+0.719	+4.484	<.001	.009	3	2
UCEC	POLR2KP2 →	+0.487	+4.551	<.001	.009	3	2
UCEC	RNMTL1P2 →	+0.194	+5.073	.001	.001	3	2
UCEC	RN7SL621P →	+0.483	+4.398	<.001	.006	3	2
UCEC	RN7SL156P →	+0.510	+4.840	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

RN7SKP211 by CASTOR1 expression — UCEC

Explore this box plot interactively →