CASTOR1

Across TCGA cell cohorts, CASTOR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,025 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CASTOR1-associated GO terms across cancer lineages are Putrescine biosynthetic process from arginine, via ornithine, Response to L-arginine, and Cellular response to L-arginine. Each is linked with CASTOR1 in more than 11 cancer types. Because this analysis shows association rather than direction, both CASTOR1-to-partner and partner-to-CASTOR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Putrescine biosynthetic process from arginine, via ornithine grouped by CASTOR1-low versus CASTOR1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CASTOR1→partner) and Y-score (partner→CASTOR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Putrescine biosynthetic process from arginine, via ornithine →	-0.185	-0.971	<.001	<.001	3	12
SKIN	Response to L-arginine →	-0.240	-1.425	<.001	<.001	3	11
SKIN	Cellular response to L-arginine →	-0.240	-1.425	<.001	<.001	3	11
OESOPHAGUS	Retrograde transport, endosome to Golgi →	+0.084	+1.210	.001	.003	2	11
LIVER	Response to water →	+0.188	+1.738	<.001	<.001	3	10
BONE	Cellular response to topologically incorrect protein →	+0.098	+1.491	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,025 associations by consensus.

Putrescine biosynthetic process from arginine, via ornithine by CASTOR1 expression — BREAST

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