CASTOR1

Across TCGA cell cohorts, CASTOR1 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CASTOR1-associated genes across cancer lineages are C8A, UCP1, and RFPL3. Each is linked with CASTOR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASTOR1-to-partner and partner-to-CASTOR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C8A grouped by CASTOR1-low versus CASTOR1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASTOR1→partner) and Y-score (partner→CASTOR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C8A →	+0.026	+3.684	<.001	.006	3	1
BLOOD_Leukemia	UCP1 →	+0.187	+3.999	.002	.005	3	1
BLOOD_Leukemia	RFPL3 →	+0.050	+4.339	<.001	.002	3	1
BLOOD_Leukemia	APOL5 →	+0.012	+4.060	.002	.003	3	1
BLOOD_Leukemia	BRDT →	+0.178	+4.342	<.001	.002	3	1
BLOOD_Leukemia	NPFFR1 →	+0.015	+4.037	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

C8A by CASTOR1 expression — LARGE_INTESTINE

Explore this box plot interactively →