CAST

Across TCGA pan-cancer cohorts, CAST mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CAST data layer compared with 29 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher CAST mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CAST expression acts as an unfavorable survival marker.

GBM, PDAC, and LSCC are the cancer types where CAST mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Tertile	All	0.303	0.519	.024	13	view →
PDAC	DFS	Quartile	II,III,IV	0.600	0.889	.019	12	view →
LSCC	OS	Tertile	II,III,IV	0.665	0.955	.014	2	view →
HNSC	DFS	Median	IV	0.920	1.000	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CAST–GBM (DFS)

Open the GBM breakdown →