CAST

Across TCGA patient cohorts, CAST RNA expression is significantly associated with the protein abundance of many other proteins, with 17,887 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CAST-associated proteins across cancer lineages are SERPINB1, CAST_S575, and ANXA2. Each is linked with CAST in more than 6 cancer types. Because this analysis shows association rather than direction, both CAST-to-partner and partner-to-CAST results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CAST versus SERPINB1 in UCEC, with a Pearson correlation of 0.45.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CAST→partner) and Y-score (partner→CAST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SERPINB1 →	+0.538	+0.631	<.001	<.001	3	7
UCEC	CAST_S575 →	+0.640	+0.736	<.001	<.001	3	7
GBM	ANXA2 →	+0.553	+0.441	<.001	<.001	3	7
GBM	S100A11 →	+0.750	+0.498	<.001	<.001	3	6
UCEC	CAST_S366 →	+1.341	+0.871	<.001	<.001	3	6
BRCA	CERT1 →	+0.316	+0.621	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,887 associations by consensus.

CAST vs SERPINB1 — UCEC

Explore this scatter interactively →