CAST

Across TCGA patient cohorts, CAST protein abundance is significantly associated with the RNA expression of many other genes, with 20,342 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CAST-associated genes across cancer lineages are CENPO, MYBL2, and CDCA7. Each is linked with CAST in more than 6 cancer types. Because this analysis shows association rather than direction, both CAST-to-partner and partner-to-CAST results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CAST versus CENPO in LSCC, with a Pearson correlation of -0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAST→partner) and Y-score (partner→CAST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CENPO →	-0.747	-0.415	<.001	<.001	3	7
LUAD	MYBL2 →	-1.582	-0.303	<.001	.002	3	7
BRCA	CDCA7 →	-1.013	-0.234	<.001	.001	3	7
GBM	MEX3A →	-1.462	-0.414	<.001	<.001	3	7
LUAD	MMP28 →	+1.666	+0.364	<.001	<.001	3	7
GBM	STMN1 →	-1.110	-0.477	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,342 associations by consensus.

CAST vs CENPO — LSCC

Explore this scatter interactively →