CAST

Across TCGA cell cohorts, CAST RNA expression is significantly associated with the RNA expression of many other genes, with 11,169 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CAST-associated genes across cancer lineages are CAPN2, CTNNA1, and ERAP1. Each is linked with CAST in more than 13 cancer types. Because this analysis shows association rather than direction, both CAST-to-partner and partner-to-CAST results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CAST versus CAPN2 in LIVER, with a Pearson correlation of 0.57.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAST→partner) and Y-score (partner→CAST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CAPN2 →	+3.056	+1.811	.001	<.001	3	14
BLOOD_Lymphoma	CTNNA1 →	+1.742	+1.011	<.001	<.001	3	13
SOFT_TISSUE	ERAP1 →	+1.863	+1.599	<.001	<.001	3	13
BONE	LNPEP →	+0.973	+1.346	<.001	<.001	3	13
BONE	MYOF →	+4.373	+1.444	<.001	<.001	3	12
KIDNEY	TMOD3 →	+0.934	+0.899	<.001	<.001	2	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,169 associations by consensus.

CAST vs CAPN2 — LIVER

Explore this scatter interactively →