CAST

Across TCGA cell cohorts, CAST RNA expression is significantly associated with the go_rna of many other GO terms, with 5,697 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CAST-associated GO terms across cancer lineages are Positive regulation of plasma membrane repair, Negative regulation of actin filament depolymerization, and Epithelial cell development. Each is linked with CAST in more than 16 cancer types. Because this analysis shows association rather than direction, both CAST-to-partner and partner-to-CAST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of plasma membrane repair grouped by CAST-low versus CAST-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CAST→partner) and Y-score (partner→CAST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of plasma membrane repair →	+0.249	+1.698	<.001	<.001	3	17
BONE	Negative regulation of actin filament depolymerization →	+0.192	+1.413	<.001	<.001	3	15
BONE	Epithelial cell development →	+0.153	+1.649	<.001	<.001	3	13
STOMACH	Wound healing →	+0.113	+1.291	<.001	<.001	3	13
URINARY_TRACT	Positive regulation of hemostasis →	+0.241	+0.972	.001	.003	3	13
LUNG_SCLC	Regulation of plasma membrane organization →	+0.205	+1.638	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,697 associations by consensus.

Positive regulation of plasma membrane repair by CAST expression — SOFT_TISSUE

Explore this box plot interactively →