CAST

Across TCGA cell cohorts, CAST mutation is significantly associated with the mutation status of many other genes, with 5,537 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CAST-associated genes across cancer lineages are CATSPER1, ITGAM, and YY1AP1. Each is linked with CAST in more than 3 cancer types. Because this analysis shows association rather than direction, both CAST-to-partner and partner-to-CAST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CATSPER1 grouped by CAST-low versus CAST-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAST→partner) and Y-score (partner→CAST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CATSPER1 →	+4.502	+5.066	.007	.007	1	4
BLOOD_Lymphoma	ITGAM →	+4.584	+4.584	.007	.007	1	4
LARGE_INTESTINE	YY1AP1 →	+3.415	+3.215	.002	.002	1	4
SOFT_TISSUE	C15orf39 →	+4.066	+5.022	.001	.001	1	3
SOFT_TISSUE	TAS1R3 →	+4.651	+5.307	<.001	<.001	1	3
SOFT_TISSUE	KCND2 →	+4.651	+5.307	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,537 associations by consensus.

CATSPER1 by CAST expression — LUNG_SCLC

Explore this box plot interactively →