CAST

Across TCGA cell cohorts, CAST mutation is significantly associated with the drug of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CAST-associated genes across cancer lineages are Niraparib, PCI-34051, and CDK9_5038. Each is linked with CAST in more than 1 cancer types. Because this analysis shows association rather than direction, both CAST-to-partner and partner-to-CAST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Niraparib grouped by CAST-low versus CAST-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAST→partner) and Y-score (partner→CAST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Niraparib →	+0.397	+2.646	.025	.047	3	1
LARGE_INTESTINE	PCI-34051 →	+0.391	+2.646	.042	.047	3	1
LARGE_INTESTINE	CDK9_5038 →	+0.623	+2.906	.023	.033	1	1
LARGE_INTESTINE	123829 →	+0.693	+2.649	.016	.046	1	1
LARGE_INTESTINE	Sabutoclax →	+0.424	+2.769	.046	.040	1	1
LARGE_INTESTINE	CX-5461 →	+0.813	+2.652	.005	.045	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Niraparib by CAST expression — LARGE_INTESTINE

Explore this box plot interactively →