CASS4

Across TCGA pan-cancer cohorts, CASS4 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CASS4 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CASS4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CASS4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

HNSC, UCEC, and LGG are the cancer types where CASS4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.102	0.756	<.001	36	view →
UCEC	DFS	Median	II,III,IV	0.942	0.301	.006	30	view →
LGG	OS	Median	All	0.300	0.830	.004	6	view →
ESCA	DFS	Median	II,III,IV	0.200	0.525	.038	6	view →
COAD	OS	Median	IV	0.082	0.659	<.001	6	view →
LUSC	DFS	Median	All	0.384	0.650	.028	4	view →
LUAD	DFS	Median	II,III,IV	0.821	0.238	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CASS4–HNSC (OS)

Open the HNSC breakdown →