CASS4

Across TCGA patient cohorts, CASS4 protein abundance is significantly associated with the RNA expression of many other genes, with 12,415 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CASS4-associated genes across cancer lineages are IL18RAP, CEACAM4, and CXCR2. Each is linked with CASS4 in more than 3 cancer types. Because this analysis shows association rather than direction, both CASS4-to-partner and partner-to-CASS4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CASS4 versus IL18RAP in OV, with a Pearson correlation of 0.90.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASS4→partner) and Y-score (partner→CASS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IL18RAP →	+1.365	+1.399	.007	.001	3	4
GBM	CEACAM4 →	+1.071	+1.111	.002	<.001	3	4
LSCC	CXCR2 →	+1.228	+0.455	<.001	<.001	3	4
OV	HCK →	+2.485	+1.399	.001	.001	3	3
OV	IFFO1 →	+2.355	+1.399	.006	.001	3	3
OV	BICC1 →	+2.840	+1.399	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,415 associations by consensus.

CASS4 vs IL18RAP — OV

Explore this scatter interactively →