CASS4

Across TCGA patient cohorts, CASS4 mutation is significantly associated with the RNA expression of many other genes, with 2,689 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASS4-associated genes across cancer lineages are PSMB7P1, MYO19, and BCCIP. Each is linked with CASS4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CASS4-to-partner and partner-to-CASS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMB7P1 grouped by CASS4-low versus CASS4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASS4→partner) and Y-score (partner→CASS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PSMB7P1 →	+0.014	+2.703	<.001	<.001	3	3
UCEC	MYO19 →	+0.378	+2.237	<.001	<.001	3	3
SKCM	BCCIP →	+0.378	+1.986	.002	<.001	3	3
SKCM	GOT1 →	+0.451	+2.491	<.001	<.001	3	3
UCEC	ZWINT →	+0.602	+2.197	<.001	<.001	3	3
UCEC	MCM2 →	+0.517	+1.606	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,689 associations by consensus.

PSMB7P1 by CASS4 expression — SKCM

Explore this box plot interactively →