CASS4

Across TCGA cell cohorts, CASS4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,023 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CASS4-associated GO terms across cancer lineages are Cellular response to type I interferon, Protein stabilization, and mRNA cis splicing, via spliceosome. Each is linked with CASS4 in more than 6 cancer types. Because this analysis shows association rather than direction, both CASS4-to-partner and partner-to-CASS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to type I interferon grouped by CASS4-low versus CASS4-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CASS4→partner) and Y-score (partner→CASS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Cellular response to type I interferon →	+0.097	+0.296	<.001	.002	3	7
LARGE_INTESTINE	Protein stabilization →	+0.050	+0.472	<.001	<.001	3	7
SOFT_TISSUE	mRNA cis splicing, via spliceosome →	+0.057	+0.831	<.001	.008	3	6
SOFT_TISSUE	Negative regulation of gene expression, epigenetic →	+0.049	+1.267	<.001	.001	3	6
LARGE_INTESTINE	Regulation of cell-substrate junction assembly →	+0.081	+0.408	<.001	.007	3	6
SKIN	Negative regulation of myoblast fusion →	+0.094	+0.250	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,023 associations by consensus.

Cellular response to type I interferon by CASS4 expression — SKIN

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