CASS4

Across TCGA cell cohorts, CASS4 mutation is significantly associated with the RNA expression of many other genes, with 698 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CASS4-associated genes across cancer lineages are EIF3L, IL7, and GSR. Each is linked with CASS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASS4-to-partner and partner-to-CASS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF3L grouped by CASS4-low versus CASS4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASS4→partner) and Y-score (partner→CASS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EIF3L →	+0.405	+1.941	.007	.009	3	2
LARGE_INTESTINE	IL7 →	+0.681	+3.129	.003	<.001	3	2
LARGE_INTESTINE	GSR →	+0.623	+3.043	.009	<.001	3	2
LARGE_INTESTINE	KLHL2 →	+0.512	+1.850	.007	.006	3	2
LARGE_INTESTINE	SEPSECS →	+0.568	+2.459	<.001	.006	3	2
LARGE_INTESTINE	ELP2 →	+0.562	+2.364	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 698 associations by consensus.

EIF3L by CASS4 expression — LARGE_INTESTINE

Explore this box plot interactively →