CASQ2

Across TCGA patient cohorts, CASQ2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASQ2-associated genes across cancer lineages are 14-3-3_beta, ERK2, and PCNA. Each is linked with CASQ2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASQ2-to-partner and partner-to-CASQ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CASQ2-low versus CASQ2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASQ2→partner) and Y-score (partner→CASQ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.098	-2.432	.009	.018	3	2
UCEC	ERK2 →	+0.145	+1.765	.044	.014	3	2
UCEC	PCNA →	+0.236	+1.765	.003	.014	3	2
UCEC	Shc_pY317 →	-0.183	-2.662	.001	<.001	3	2
UCEC	Tuberin →	+0.327	+2.710	.001	.003	3	2
UCEC	ATM →	-0.557	-2.169	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

14-3-3_beta by CASQ2 expression — UCEC

Explore this box plot interactively →