CASQ1

Across TCGA patient cohorts, CASQ1 mutation is significantly associated with the RNA expression of many other genes, with 3,685 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASQ1-associated genes across cancer lineages are TRGJP2, MTCO1P35, and NTAN1. Each is linked with CASQ1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CASQ1-to-partner and partner-to-CASQ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRGJP2 grouped by CASQ1-low versus CASQ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASQ1→partner) and Y-score (partner→CASQ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRGJP2 →	+0.387	+1.718	.001	.007	3	3
SKCM	MTCO1P35 →	+0.093	+4.640	<.001	.003	3	2
UCEC	NTAN1 →	+0.474	+2.124	<.001	<.001	3	2
UCEC	DEPDC4 →	+0.275	+3.031	<.001	<.001	3	2
UCEC	PATL1 →	+0.668	+3.010	<.001	<.001	3	2
UCEC	TRAPPC2L →	+0.386	+2.534	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,685 associations by consensus.

TRGJP2 by CASQ1 expression — UCEC

Explore this box plot interactively →