CASQ1

Across TCGA patient cohorts, CASQ1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASQ1-associated genes across cancer lineages are MEK1, Shc_pY317, and Src_pY527. Each is linked with CASQ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASQ1-to-partner and partner-to-CASQ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CASQ1-low versus CASQ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASQ1→partner) and Y-score (partner→CASQ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.450	+3.087	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.189	-1.925	<.001	.005	3	2
UCEC	Src_pY527 →	-0.449	-2.700	.003	.005	3	2
UCEC	ATM →	-0.715	-2.807	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.597	+2.242	.005	.005	3	2
UCEC	Chk2_pT68 →	-0.154	-1.584	.021	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

MEK1 by CASQ1 expression — UCEC

Explore this box plot interactively →