CASP9

Across TCGA patient cohorts, CASP9 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASP9-associated genes across cancer lineages are PDCD4, TIGAR, and eIF4E. Each is linked with CASP9 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP9-to-partner and partner-to-CASP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by CASP9-low versus CASP9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP9→partner) and Y-score (partner→CASP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.666	-1.807	<.001	.027	3	2
UCEC	TIGAR →	+0.176	+2.348	.005	.003	3	2
UCEC	eIF4E →	+0.177	+3.700	.042	.001	3	1
UCEC	IGFBP2 →	-0.585	-1.807	.029	.027	3	1
UCEC	JNK_pT183_Y185 →	-0.159	-2.321	.022	.034	3	1
UCEC	MEK1 →	+0.482	+3.700	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

PDCD4 by CASP9 expression — UCEC

Explore this box plot interactively →