CASP9

Across TCGA cell cohorts, CASP9 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CASP9-associated genes across cancer lineages are LYZL4, OR4K2, and BPIFB6. Each is linked with CASP9 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP9-to-partner and partner-to-CASP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYZL4 grouped by CASP9-low versus CASP9-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP9→partner) and Y-score (partner→CASP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LYZL4 →	+0.049	+4.152	.005	.009	3	1
BLOOD_Leukemia	OR4K2 →	+0.031	+4.969	<.001	.003	3	1
BLOOD_Leukemia	BPIFB6 →	+0.047	+4.969	<.001	.003	3	1
BLOOD_Leukemia	S100A7A →	+0.042	+4.152	<.001	.009	3	1
BLOOD_Leukemia	BPIFB3 →	+0.161	+4.874	<.001	.002	3	1
OVARY	ASB17 →	+0.023	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

LYZL4 by CASP9 expression — BLOOD_Leukemia

Explore this box plot interactively →