CASP8AP2

Across TCGA pan-cancer cohorts, CASP8AP2 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CASP8AP2 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CASP8AP2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CASP8AP2 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where CASP8AP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	1.000	0.915	.011	15	view →
PDAC	OS	Quartile	II,III,IV	0.307	0.819	.010	5	view →
LUAD	OS	Median	III,IV	0.247	0.787	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CASP8AP2–LSCC (OS)

Open the LSCC breakdown →