CASP8

Across TCGA patient cohorts, CASP8 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASP8-associated genes across cancer lineages are S6_pS240_S244, Caspase-7-cleavedD198, and Src_pY416. Each is linked with CASP8 in more than 2 cancer types. Because this analysis shows association rather than direction, both CASP8-to-partner and partner-to-CASP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by CASP8-low versus CASP8-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP8→partner) and Y-score (partner→CASP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	S6_pS240_S244 →	+0.838	+3.321	.003	.007	3	3
UCEC	Caspase-7-cleavedD198 →	+0.581	+2.584	<.001	<.001	3	3
HNSC	Src_pY416 →	+0.427	+2.700	.015	.005	3	2
BRCA	SETD2 →	-0.181	-2.439	.022	.021	3	2
COAD	FOXO3a →	-0.263	-3.161	<.001	.019	3	2
COAD	Heregulin →	-0.162	-3.127	.035	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

S6_pS240_S244 by CASP8 expression — HNSC

Explore this box plot interactively →