CASP8

Across TCGA cell cohorts, CASP8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,001 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CASP8-associated GO terms across cancer lineages are Death-inducing signaling complex assembly, Regulation of necroptotic process, and Positive regulation of plasma membrane repair. Each is linked with CASP8 in more than 17 cancer types. Because this analysis shows association rather than direction, both CASP8-to-partner and partner-to-CASP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Death-inducing signaling complex assembly grouped by CASP8-low versus CASP8-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP8→partner) and Y-score (partner→CASP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Death-inducing signaling complex assembly →	+0.361	+1.950	.001	<.001	3	18
BONE	Regulation of necroptotic process →	+0.080	+1.297	.006	.006	3	13
BLOOD_Lymphoma	Positive regulation of plasma membrane repair →	+0.187	+0.761	.005	<.001	3	13
CNS	Regulation of programmed necrotic cell death →	+0.082	+1.441	.002	<.001	3	12
LUNG_SCLC	Skeletal myofibril assembly →	+0.614	+1.403	.001	.001	3	11
LUNG_NSCLC_LUAD	Intracellular receptor signaling pathway →	+0.049	+1.019	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,001 associations by consensus.

Death-inducing signaling complex assembly by CASP8 expression — LUNG_SCLC

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