CASP8

Across TCGA cell cohorts, CASP8 mutation is significantly associated with the RNA expression of many other genes, with 193 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CASP8-associated genes across cancer lineages are ASB17, C12orf40, and ARMH2. Each is linked with CASP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP8-to-partner and partner-to-CASP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by CASP8-low versus CASP8-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP8→partner) and Y-score (partner→CASP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1
OVARY	ARMH2 →	+0.052	+4.228	<.001	.006	3	1
BLOOD_Lymphoma	PRKAG3 →	+0.285	+3.502	<.001	.006	3	1
BLOOD_Lymphoma	ZC2HC1B →	+0.131	+3.058	<.001	.006	3	1
BLOOD_Lymphoma	XAGE2 →	+0.040	+3.169	.008	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 193 associations by consensus.

ASB17 by CASP8 expression — OVARY

Explore this box plot interactively →