CASP7

Across TCGA patient cohorts, CASP7 mutation is significantly associated with the RNA expression of many other genes, with 2,213 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASP7-associated genes across cancer lineages are WASHC3P1, MIR4760, and HMGB3P3. Each is linked with CASP7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP7-to-partner and partner-to-CASP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WASHC3P1 grouped by CASP7-low versus CASP7-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP7→partner) and Y-score (partner→CASP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	WASHC3P1 →	+0.057	+4.147	.003	.008	3	2
BRCA	MIR4760 →	+0.397	+8.055	<.001	.007	3	2
UCEC	HMGB3P3 →	+0.151	+1.921	<.001	.006	3	2
UCEC	RNU6-1149P →	+0.301	+2.170	<.001	.007	3	2
UCEC	RNA5SP420 →	+0.498	+1.867	<.001	.007	3	2
BLCA	OR7E117P →	+0.045	+5.038	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,213 associations by consensus.

WASHC3P1 by CASP7 expression — SKCM

Explore this box plot interactively →