CASP7

Across TCGA patient cohorts, CASP7 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASP7-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and MEK1. Each is linked with CASP7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP7-to-partner and partner-to-CASP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CASP7-low versus CASP7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP7→partner) and Y-score (partner→CASP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.207	+3.183	.024	.009	3	1
UCEC	A-Raf_pS299 →	-0.132	-3.321	.011	.010	3	1
UCEC	MEK1 →	+0.448	+2.807	.005	.003	3	1
UCEC	MSH2 →	-0.250	-2.973	.013	.035	3	1
UCEC	mTOR_pS2448 →	-0.178	-2.446	.006	.018	3	1
UCEC	Notch1 →	+0.168	+1.750	.006	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

eIF4E by CASP7 expression — UCEC

Explore this box plot interactively →