CASP7

Across TCGA cell cohorts, CASP7 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,477 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CASP7-associated GO terms across cancer lineages are Response to staurosporine, Cellular response to staurosporine, and CD8-positive, alpha-beta T cell homeostasis. Each is linked with CASP7 in more than 19 cancer types. Because this analysis shows association rather than direction, both CASP7-to-partner and partner-to-CASP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to staurosporine grouped by CASP7-low versus CASP7-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP7→partner) and Y-score (partner→CASP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Response to staurosporine →	+0.280	+1.384	<.001	<.001	3	20
URINARY_TRACT	Cellular response to staurosporine →	+0.280	+1.384	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	CD8-positive, alpha-beta T cell homeostasis →	+0.138	+0.817	.002	.008	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of regulatory T cell differentiation →	+0.158	+0.778	.003	.006	3	11
URINARY_TRACT	CD8-positive, alpha-beta T cell differentiation →	+0.120	+0.829	<.001	<.001	2	12
SKIN	Positive regulation of neuron apoptotic process →	+0.104	+0.750	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,477 associations by consensus.

Response to staurosporine by CASP7 expression — URINARY_TRACT

Explore this box plot interactively →