CASP6

Across TCGA pan-cancer cohorts, CASP6 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CASP6’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CASP6 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CASP6 is over-expressed in tumor.

LUAD, HNSC, and LSCC are the cancer types where CASP6 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CASP6 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.598	<.001	9	view →
HNSC	Male	IV	+0.370	<.001	8	view →
LSCC	Male	III,IV	+0.311	<.001	7	view →
OV	All	All	+0.473	.023	2	view →
PDAC	All	IV	+0.367	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CASP6–LUAD

Open the LUAD breakdown →